The Effect of Oxygen Tension on the Differentiation of Outgrowth Cells from Embryoid Bodies Produced by Mouse Induced Pluripotent Stem Cells

The purpose of this study was to investigate the effects oxygen tension on mouse induced pluripotent stem (iPS) cells by assessing differentiation in terms embryoid body (EB) size and mRNA protein expression levels collagen type 1 Runx2. EBs outgrowth (OGCs) were cultured conditions hypoxia (2%), normoxia (21%) hyperoxia (35%). Significantly larger observed groups compared group Days 8 10. had significantly higher Runx2 10 26, these lower than 26. These results suggest that accelerates enlargement iPS cells.